Corticosteroid Treatment for Community-Acquired Pneumonia - The STEP Trial

Inclusion Criteria: 1. Patients 18 years of age or older admitted for hospitalization from the community or a nursing home with CAP. 2. CAP will be defined by a new infiltrate on chest radiograph and the presence of one or several of the following acute respiratory signs or symptoms: * cough * sputum production * dyspnea * core body temperature \>38.0° C * auscultatory findings of abnormal breath sounds and rales * leukocyte count \>10 or \<4 x 109 cells L-1 (1) Exclusion Criteria: 1. Patients or family members unable to give written informed consent, e.g. with severe dementia. 2. Patients with active intravenous drug use. 3. Severe immunosuppression (e.g. patients infected with human immunodeficiency virus infection and a CD4 count below 350 x 109/L, patients on immunosuppressive therapy after solid organ transplantation and neutropenic patients with neutrophil count \< 500 x 109/L and patients under chemotherapy with neutrophils 500-1000 x 109/L with an expected decrease to values \< 500 x 109/L); patients with cystic fibrosis as well as patients with active tuberculosis. 4. Patients with acute burn injury 5. Patients with acute gastrointestinal bleeding within 3 months of the current hospitalization 6. Patients with an acute concomitant condition requiring more than 0.5mg/kg/d prednisone equivalent 7. Pregnancy or breast feeding 8. Patients with known adrenal insufficiency