Hepatitis B Surface Antigen(HBsAg) Loss in Chronic Hepatitis B Patients With Low Viral Load

Inclusion Criteria: * Male and female patients \> 18 and ≤ 70 years of age * Positive HBsAg for more than 6 months. * Negative for HBeAg for more than 6 months. * HBV DNA \< 2.0 E04 IU/mL * Serum ALT \< 5 \* ULN as determined by two values taken \>14 days apart during the six months before the first dose of study drug with at least one of the determinations obtained during the screening period. * Negative urine or serum pregnancy test (for women of childbearing potential) documented within the 24-hour period prior to the first dose of test drug. Exclusion Criteria: * Patients co-infected with HCV, HIV or who have decompensated liver disease, hepato-cellular carcinoma, significant cardiac disease, significant renal disease, seizure disorders or severe retinopathy. * Patients who have received nucleos(t)ide analogues for their chronic hepatitis B within 6 weeks before enrollment or have received Peg-IFN within 3 months before enrollment. * Patients must not have received any other systemic anti-viral, anti-neoplastic or immuno-modulatory treatment (including supraphysiologic doses of steroids or radiation) \<3 months prior to the first dose of study drug or the expectation that such treatment will be needed at any time during the study. * Positive test at screening for anti-HAV IgM, anti-HIV, HCV RNA. (Patients that have cleared the hepatitis C virus can be included in the study) * Patients who are expected to need systemic antiviral therapy other than that provided by the study at any time during their participation in the study are also excluded. Exception: patients who have had a limited (\<7 day) course of acyclovir for herpetic lesions more than 1 month prior to the first administration of test drug are not excluded. * Evidence of decompensated liver disease (Child pugh B-C) * Serum total bilirubin \> twice the upper limit of normal at screening * History or other evidence of bleeding from esophageal varices or other conditions consistent with decompensated liver disease. * History or other evidence of a medical condition associated with chronic liver disease other than HBV (e.g., hemochromatosis, autoimmune hepatitis, metabolic liver diseases including Wilson's disease and alfa1-antitrypsin deficiency, alcoholic liver disease, toxin exposures, thalassemia). * Women with ongoing pregnancy or who are breast feeding. * Neutrophil count \<1500 cells/mm3 or platelet count \<80,000 cells/mm3 at screening. * Hemoglobin \< 7.1 mmol/L (\< 11.5 g/dL) for females and \< 7.8 mmol/L (\< 12.5 g/dL) for men at screening. * Serum creatinine level \>1.5 times the upper limit of normal at screening. * Unstable ongoing severe psychiatric disease, especially depression (stable patients can be included). * History of immunologically mediated disease (e.g., inflammatory bowel disease, idiopathic thrombocytopenic purpura, lupus erythematosus, autoimmune hemolytic anemia, scleroderma, severe psoriasis, rheumatoid arthritis). * History or other evidence of chronic pulmonary and cardiac disease associated with functional limitation. Severe cardiac disease (e.g., NYHA Functional Class III or IV, myocardial infarction within 6 months, ventricular tachyarrhythmias requiring ongoing treatment, unstable angina or other significant cardiovascular diseases). * History of a severe seizure disorder or current anticonvulsant use and clinically unstable disease. * Evidence of an active or suspected cancer or a history of malignancy where the risk of recurrence is \>20% within 5 years. Patients with a lesion suspicious of hepatic malignancy on a screening imaging study will only be eligible if the likelihood of carcinoma is \<10% following an appropriate evaluation. * Major organ transplantation. (patients with skin, cornea or bone transplantation are allowed to be included into the study) * Thyroid disease with thyroid function poorly controlled on prescribed medications. Patients with elevated thyroid stimulating hormone or T4 concentrations, with elevation of antibodies to thyroid peroxidase and any clinical manifestations of thyroid disease that are not stable on prescribed medication are excluded. Stable patients can be included. * History or other evidence of severe retinopathy (e.g. CMV retinitis, macula degeneration) or clinically relevant ophthalmological disorder due to diabetes mellitus or hypertension. * Inability or unwillingness to provide informed consent or abide by the requirements of the study. * History or other evidence of severe illness or any other conditions which would make the patient, in the opinion of the investigator, unsuitable for the study. * Patients with a value of alfa-fetoprotein \>100 ng/mL are excluded, unless stability (less than 10% increase) has been documented over at least the previous 3 months. * Evidence of current hard drug(s) (i.e. cannabis products are allowed) and/or alcohol abuse (20g/day for women and 30g/day for men). * Patients included in another trial or having been given investigational drugs within 12 weeks prior to screening.