Dexamethasone Tolerability in the Treatment of Acute Asthma in Children

IWK Health Centre430 enrolled

Overview

The purpose of this study is to assess whether smaller volumes of oral dexamethasone result in better tolerability, specifically less vomiting, in pediatric patients during an acute asthma exacerbation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

430

Conditions

Asthma

Interventions

Ora SweetDRUG

A pharmaceutical suspending vehicle and flavouring agent added to the dexamethasone. All arms received the same amount of dexamethasone based on the child's weight, only in different volumes.

DexamethasoneDRUG

Eligibility

Sex: ALLMin age: 2 YearsMax age: 14 Years

Medical Language ↔ Plain English

Inclusion Criteria: * acute asthma exacerbation * requiring oral systemic corticosteroids for management Exclusion Criteria: * preference for pills over liquid formulation * history of Nissen fundoplication surgery * needed immediate airway intervention * require oral medications to be given via a G or J tube * if patient care would be compromised * enrolled in the study on a previous visit.

Locations (1)

IWK Health Centre

Halifax, Nova Scotia, Canada

Outcomes

Primary Outcomes

The primary objective of this study was to assess whether smaller volumes of oral dexamethasone resulted in better tolerability, specifically less vomiting, in pediatric patients with an acute exacerbation of asthma.

Time frame: During Emergency Department visit

Secondary Outcomes

To evaluate asthma symptom control post emergency room visit for acute asthma exacerbation.

Time frame: 7-14 days following emergency dept visit

Data from ClinicalTrials.gov

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