Bone Graft Materials Observational Registry

Inclusion Criteria: * The patient has failed conservative treatment and is a candidate for spinal fusion surgery. * The patient is ≥18 years old and of legal age of consent. * The patient is, in the investigator's opinion, psychosocially, mentally, and physically able to fully comply with this protocol, including the post-operative regimen, required follow-up visits, the filling out of required forms, and have the ability to understand and give written informed consent. * The patient is skeletally mature (epiphyses closed). * The patient has signed the IRB approved informed consent. * The patient is willing and able to participate in post-operative clinical and radiographic follow up evaluations for 2 years. Exclusion Criteria: * Patient has systemic infection or infection at the surgical site. * Patient has a medical condition that would interfere with post-operative assessments and care (i.e., neuromuscular disease, psychiatric disease, paraplegia, quadriplegia, etc.). * Patient is in poor general health or any concurrent disease process that would place the patient in excessive risk to surgery (i.e., significant circulatory or pulmonary problems, or cardiac disease). * Patient has a history (present or past) of substance abuse (recreational drugs, prescription drugs or alcohol) that in the investigator's opinion may interfere with protocol assessments and/or with the patient's ability to complete the protocol required follow-up. * The patient is pregnant/breastfeeding at the time of enrollment, or plans to become pregnant during the course of the study. * Patient is participating in another investigational study, which could confound results.