Phase I STEBVax in Healthy Adults

Inclusion Criteria: * Ability to provide written informed consent. * Age 18 - 40 years, inclusive. * Good "general health" as determined by vital signs (heart rate \<100 bpm; blood pressure systolic \> 90 mm Hg and less than or equal to 140 mm Hg; diastolic \> 50 mm Hg and less than or equal to 90 mm Hg; oral temperature \<100.4 degrees Fahrenheit), medical history, and a physical examination within 45 days before administration of Recombinant Staphylococcal Enterotoxin B Vaccine (STEBVax). Blood pressure outside this range may be repeated once on another occasion. * Expressed interest and availability to fulfill the study requirements * Agrees not to become pregnant from the time of study enrollment until at least 90 days after the last administration of STEBVax; if a woman is sexually active and capable of conception (i.e., no history of hysterectomy or tubal ligation), she must agree to use hormonal or barrier birth control such as implants, injectables, combined oral contraceptives, some intrauterine devices (IUDs), condoms with spermicidal agents, or must have a vasectomized partner, or must be sexually abstinent. A woman is eligible if she is monogamous with a vasectomized male * Agrees not to participate in another clinical trial at any time during the study period. * Agrees to remain in the Baltimore-Washington metropolitan area for 7 days after vaccination. Exclusion Criteria: * History of any of the following medical illnesses: * Toxic shock syndrome * Asthma requiring daily prescription medication * Psychiatric disorder requiring hospitalization * Anaphylaxis/hypersensitivity reactions to glycine, or alum (vaccine components) * Coagulopathy * Kidney disease * Diabetes * Cancer * Heart disease (hospitalization for a heart attack, arrhythmia, or syncope) * Vascular disease (peripheral vascular disease, coronary artery disease, stroke) * Arthritis * Autoimmune disease (e.g., lupus erythematosis, rheumatoid arthritis) * Unconsciousness (other than a single brief "concussion") * Seizures (other than febrile seizures as a child \<5 years old) * Recurrent infections (more than 3 hospitalizations for invasive bacterial infections such as pneumonia or meningitis) * Any current illness requiring regular medication therapy other than vitamins or birth control * Any clinically significant abnormality including but not limited to: * Murmur (other than a functional murmur) * Focal neurological * Hepatosplenomegaly * Lymphadenopathy * Jaundice * Lab abnormality, as listed below. Toxicity grading scale provided in Appendix B, Normal ranges provided in Appendix C. Laboratories with abnormalities possibly transient in nature may be repeated one time. * Hemoglobin, White blood cell count, Neutrophil count, or Platelet count outside the normal range * PT, PTT above the normal range * Sodium, or potassium outside the normal range * Creatinine above normal range * Glucose outside the normal range (65 to \<110 mg/dL is acceptable if non-fasting test) * AST, ALT, alkaline phosphatase, total bilirubin of grade 1 or greater on the toxicity grading scale * Urinalysis with proteinuria or hematuria * Positive serology for hepatitis C or HIV antibody or hepatitis B surface antigen (Subjects will be informed if their results are positive for hepatitis C, HIV antibody or hepatitis B surface antigen and will be referred to a primary care provider for follow up of these abnormal laboratory tests.) * Have a positive urine drug screen. * For women, positive serum pregnancy test within 45 days and urine pregnancy test within 24 hours of administering STEBVax at days 0 and for the highest dose group who receive two doses of vaccine, on day 21. * Nursing mother * Temperature \> 38.0 degrees C (100.4 degrees F) or symptoms of an acute self-limited illness such as an upper respiratory infection or gastroenteritis within 7 days before administration of STEBVax * Medical, occupational, or family problems as a result of alcohol or illicit drug use during the past 12 months * Failure to pass written examination (70 percent correct answers required to pass) on the first attempt. (The exam is administered to assess and document comprehension of the material presented which covers all aspects of the study including the purpose, procedures, risks, benefits and pertinent microbiology). * Receipt of an experimental agent (vaccine, drug, device, etc.) within 28 days before administration of STEBVax or expects to receive an experimental agent during the study period. * Receipt of any licensed vaccine within 2 weeks (for inactivated vaccines) or 4 weeks (for live vaccines) before vaccination in this study or expects to receive a licensed vaccine before vaccination in this study. * Known sensitivity to any ingredient in STEBVax (recombinant protein, glycine, sodium chloride, alum) * Prosthetic joint * Receipt of immunoglobulin or other blood product within the 3 months prior to vaccination in this study. * Immunosuppression as a result of an underlying illness or treatment with immunosuppressive or cytotoxic drugs, or use of anticancer chemotherapy or radiation therapy within the preceding 36 months. * Long-term use (\> 2 weeks) of oral or parenteral steroids (glucocorticoids), or high-dose inhaled steroids (\>800 mcg/day of beclomethasone dipropionate or equivalent) within the preceding 6 months (nasal and topical steroids are allowed). * Other condition that in the opinion of the investigator would jeopardize the safety or rights of a volunteer participating in the trial or would render the subject unable to comply with the protocol.