Levobupivacaine on Heart Rate Variability (HRV) in Spinal Anesthesia

National Taiwan University Hospital70 enrolled

Overview

The purpose of this study is to compare if the effect of levobupivacaine on autonomic nervous system smaller than that of bupivacaine.

Obtain the heart rate variability (in means and standard deviation, including the high frequency, low frequency and its ratio) data of before and after spinal anesthesia with ECG (and Heart Rate Variability Analyzer) in 2 groups. Meanwhile, record the blood pressure on each subject.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Spinal Anesthesia

Interventions

bupivacaine, levobupivacaineDRUG

intrathecal injection 15\~20mg(for Levobupivacaine) or 10\~15mg(for Bupivacaine) once

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Indicated for spinal anesthesia Exclusion Criteria: * Allergic reaction to local anesthetics * Coagulopathy * Severe spinal deformity * Cardiac diseases * Metabolic diseases (such as DM, thyroid or adrenal diseases)

Locations (1)

Department of Anesthesiology, National Taiwan University Hospital, Yun-Lin Branch

Yun-Lin County, Taiwan

RECRUITING

Outcomes

Primary Outcomes

HRV values

Time frame: 5 minutes after drug administration

Central Contacts

Shih-Yu Chen, M.D.

CONTACT

886-5-5323911 hitantc@gmail.com

Data from ClinicalTrials.gov

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