Effect of Lidocaine in Antiarrhythmic Dosage on Postoperative Cognitive Dysfunction in Supratentorial Craniotomy Dysfunction in Supratentorial Craniotomy

Capital Medical University100 enrolled

Overview

The purpose of this study is to investigate the effect of lidocaine in antiarrhythmic dosage on postoperative cognitive dysfunction in supratentorial craniotomy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

DOUBLE

Enrollment

100

Conditions

Supratentorial Craniotomy Dysfunction

Interventions

lidocaineDRUG

Lidocaine arm: lidocaine (2%) as an intravenous bolus (1.5 mg/kg) during induction followed by an intravenous infusion (2 mg. kg(-1).h(-1)) after induction until at the end of surgery

salineDRUG

Saline arm: infused at the same rate as lidocaine

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 18-60 years old, ASA physical status I or II, BMI\<30 * Scheduled for elective supratentorial craniotomy * MMSE\<24 before operation * Cooperative and given informed consent in person Exclusion Criteria: * History of mental or psychiatric disorders * Contraindicated to internal jugular venous catheterization * Pregnant or lactating female * History of systemic malignant tumor or diabetes * Previously treated with this protocol or participated in another study within previous 30 days * Suspected history of allergic reaction or intolerance to amides or other anesthetic agents in this study * History of alcohol abuse and/or drug abuse within previous one year * History or a family history of malignant hyperthermia

Locations (1)

Department of Anesthesiology,Beijing Tiantan Hospital, Capital Medical University

Beijing, Beijing Municipality, China

Outcomes

Primary Outcomes

Mini-Mental State Examination (MMSE)

Time frame: Preoperatively, 3 days and 3 months postoperatively

Montreal Cognitive Assessment (MoCA)

Time frame: Preoperatively, 3 days and 3 months postoperatively

Hamilton Depression Scale (HAMD)

Time frame: Preoperatively, 3 days and 3 months postoperatively

Clinical Dementia Rating (CDR)

Time frame: Preoperatively, 3 days and 3 months postoperatively

Confusion Assessment Method for the Diagnosis of Delirium in the Intensive Care unit (ICU) (CAM-ICU)

Time frame: 1 day and 3 days postoperatively

Secondary Outcomes

AjDO2 (Arterial Jugular Difference)

Time frame: Injection of test dosage, 1 hour, 2 hours, 3 hours after injection of test dosage, end of surgery

AjDGlc

Time frame: Injection of test dosage, 1 hour, 2 hours, 3 hours after injection of test dosage, end of surgery

AjDGlutamate

Time frame: Injection of test dosage, 1 hour, 2 hours, 3 hours after injection of test dosage, end of surgery

AjDLct

Time frame: Injection of test dosage, 1 hour, 2 hours, 3 hours after injection of test dosage, end of surgery

S100

Time frame: Injection of test dosage, end of surgery, 24 hours after operation

Data from ClinicalTrials.gov

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