Multi-Year Study of Fluzone High-Dose Influenza Vaccine Compared With Fluzone® Vaccine in Adults Aged 65 Years and Older

Inclusion Criteria : * Aged ≥ 65 years on the day of vaccination * Informed consent form signed and dated. * Able to attend all scheduled visits and to comply with all trial procedures. Exclusion Criteria : * Participation in another interventional clinical trial investigating a vaccine, drug, medical device, herbal supplement, or a medical procedure in the 4 weeks preceding the trial vaccination or planned participation in another clinical trial investigating a vaccine, drug, medical device, herbal supplement, or a medical procedure during each year of participation in the study trial. * Vaccination against influenza in the 6 months preceding the trial vaccination. * Systemic hypersensitivity to eggs, chicken proteins, or any of the vaccine components, or a history of a life-threatening reaction to Fluzone vaccine or to a vaccine containing any of the same substances. * Personal history of Guillain-Barré syndrome. * Dementia or any other cognitive condition at a stage that could interfere with following the trial procedures. * Thrombocytopenia, bleeding disorder, or anticoagulation therapy contraindicating intramuscular (IM) vaccination. * Known or suspected human immunodeficiency virus (HIV), Hepatitis B surface antigen (HBsAg), or Hepatitis C seropositivity. * Alcohol abuse or drug addiction that could interfere with the subject's ability to comply with trial procedures. * Subject deprived of freedom by an administrative or court order, or in an emergency setting, or hospitalized without his/her consent. * Bedridden subjects.