Effectiveness Study of Single Photon Emission Computed Tomography (SPECT) Versus Positron Emission Tomography (PET) Myocardial Perfusion Imaging

Aspire Foundation330 enrolled

Overview

The purpose of this study is to compare pharmacologic stress myocardial perfusion PET with pharmacologic stress myocardial perfusion SPECT in a near-simultaneous, head-to-head comparison in the same patient. The investigators hypothesize that pharmacologic stress myocardial perfusion PET will prove superior to pharmacologic stress myocardial perfusion SPECT as a first-line diagnostic test for higher-risk patients with known coronary artery disease (CAD) who present with symptoms consistent with possible worsening of their CAD.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

330

Conditions

Coronary Artery Disease

Interventions

Myocardial perfusion imaging

Eligibility

Sex: ALLMin age: 30 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * History of coronary artery disease * New or worsening symptoms * Out-patients and in-hospital patients Exclusion Criteria: * Creatinine above 2.5 mg% * PCI within prior 6 months * Pregnant females * Cardiomyopathy (LVEF below 40%) * Significant valvular heart disease * Body mass index greater than 38

Outcomes

Primary Outcomes

Diagnostic failure of SPECT vs PET

Time frame: 60 days

Secondary Outcomes

Composite of diagnostic or clinical failure

Time frame: 12 months

Each of individual components of clinical failure

Time frame: 12 months

Relative effect on quality of life

Time frame: 3 months, 6 months

Relative direct and downstream costs

Time frame: 3 months, 6 months, 12 months