Effects of Repeat Dosing of GSK1521498

Inclusion Criteria: * Healthy as determined by a responsible and experienced physician * Non smoking male or female between 18 and 60 years of age inclusive * A female subject of child-bearing potential must use a contraception method listed in the protocol prior to the start of dosing until at least 14 days after receiving the last dose of study medication. * Male subjects must agree to use one of the contraception methods listed in the protocol from the first dose of study medication until at least 84 days after receiving the last dose of study medication. * BMI within the range 25 - 35 kg/m2 (inclusive). * Capable of giving written informed consent, which includes compliance with the requirements and restrictions listed in the consent form. * QTcB or QTcF \< 450 msec. * Suitable for repeat cannulation. Exclusion Criteria: * Has clinically significant rhythm abnormalities identified during 24-hour screening Holter assessment. * Systolic blood pressure greater than 150 mmHg and/or diastolic BP greater than 90 mmHg. * Diabetes mellitus or physician-diagnosed dyslipidaemia requiring treatment * Self-administered Beck Depression Inventory II scale total score greater than 13 or suicide question score greater than zero at screening. * Positive pre-study drug/alcohol screen * Positive pre-study Hepatitis B surface antigen or positive Hepatitis C antibody result within 3 months of screening * Positive test for HIV antibody. * Pregnant or lactating females * Smoking history that includes regular use of tobacco or nicotine-containing products within 6 months prior to screening. * A history of any thyroid dysfunction or an abnormal thyroid function test * History of regular high level of alcohol consumption within 6 months of the study * Participated in a clinical trial involving an investigational product within 90 days * Exposure to more than four new chemical entities within 12 months prior to the first dosing day. * Use of prescription or non-prescription drugs, including vitamins, herbal and dietary supplements (including St John's Wort) within 7 days prior to the first dose of study medication * History of any gastrointestinal or hepatic conditions or procedures that could affect absorption of the investigational product. * History of sensitivity to any of the study medications, or components thereof or a history of drug or other allergy that contraindicates participation. * Where participation in the study would result in donation of blood or blood products in excess of 500 mL within a 56 day period. * Unwillingness or inability to follow the procedures outlined in the protocol, including abstaining from consumption of caffeine-or xanthine containing products for 24 hours prior to dosing until the post-dose assessment, use of illicit drugs, refrain from alcohol for 24 hours prior to dosing until final post-dose assessment,, consumption of red wine, seville oranges, grapefruit or grapefruit juice from 7 days prior to the first dose of study medication until after collection of the final pharmacokinetic blood sample. * Any finding that would preclude safe use of Echo MRI scanning. These include: a history of panic attacks and/or claustrophobia, pacemaker, implanted hearing aid, metallic body piercing and/or other metal implants that cannot be removed, the opinion of the Investigator the subject exceeds size limitations for the instrument. * Mentally or legally incapacitated