The PHP study aims to delineate gene products involved in high on-treatment platelet reactivity in aspirin-treated cardiovascular patients.
The PHP study aims to delineate gene products involved in high on-treatment platelet reactivity in aspirin-treated cardiovascular patients using a system biology approach that include proteomics analysis of selected platelet sub-fractions in patients displaying extreme phenotype. Main objective: * to characterize the proteome profile of platelet hyperreactivity in aspirin-treated cardiovascular patients Secondary objectives: * to characterize the platelet hyperreactivity phenotype in cardiovascular patients treated with aspirin * to determine genetic polymorphisms associated with platelet hyperreactivity
Study Type
OBSERVATIONAL
Enrollment
110
University Hospital Geneva
Geneva, Switzerland
proteome profile of platelet hyperreactivity
to characterize the proteome profile of platelet hyperreactivity in aspirin-treated cardiovascular patients
Time frame: cross sectional
platelet hyperreactivity phenotype in cardiovascular patients treated with aspirin
Time frame: cross sectional
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