This trial was conducted in Europe. The aim of this clinical trial was to evaluate if the pharmacokinetic and safety profiles of NN1250 (insulin degludec) are altered to such an extent that the dose should be adjusted in subjects with impaired liver function compared to the dose for subjects with normal liver function.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
12
The dose level will be one single dose of 0.4 units per kg body weight injected s.c. (subcutaneously, under the skin)
Novo Nordisk Investigational Site
Bratislava, Slovakia
Area under the NN1250 concentration-time curve after single-dose
Time frame: from 0 to 120 hours
Maximum observed NN1250 concentration after single-dose
Time frame: from 0 to 120 hours
Renal clearance of NN1250
Time frame: from 0 to 24 hours
Number of adverse events
Time frame: from Visit 2, Day -1 until Follow-up Visit
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