Therapeutic Intensification Plus Immunomodulation to Decrease the HIV-1 Viral Reservoir

Inclusion Criteria: * HIV-1 infection * At least 3 years of ART without interruption (less than one month cumulative) * ART regimen unchanged in the 3 months prior to screening * One HIV plasma viral load (RNA) documented at least 3 years prior to entry, and at least 2 HIV plasma viral load (RNA) documented per year thereafter * HIV plasma viral load (RNA) ≤ 500 copies/mL at least 3 years prior to entry, and HIV plasma viral load \< 500 copies/mL for \>90% of the measures thereafter * HIV plasma viral load (RNA) below the limit of detection for all values within the past year (one virologic blip allowed) * HIV plasma viral load below the limit of detection within 60 days of entry * CD4+ count ≥ 350 cells/mm3 within 60 days of entry * Proviral DNA ≥10 and ≤1000 copies/106 PBMCs within 75 days of entry * Adeno5 neutralizing antibody titers of 250 or less within 75 days of entry * Hemoglobin ≥ 10 g/dL within 60 days of entry * Platelets ≥ 100,000 per microliter within 60 days of entry * Hepatic transaminases (ALT and AST) ≤ 2.5 x ULN within 60 days of entry * Creatinine clearance \> 50 mL/min by the Cockcroft-Gault equation within 60 days of entry Exclusion Criteria: * Sexually active men and women who will not practice at least one form of barrier birth control (male partner using condoms, female partner using condoms, other barrier contraception, etc) * Pregnancy * Inability or unwillingness to provide informed consent * HBsAg positive * HCV antibody positive or HCV RNA detectable * Previous use of an integrase inhibitor (ie raltegravir) or a CCR5 inhibitor (ie maraviroc, vicriviroc). Use of raltegravir for non-treatment failure indications such as intensification or toxicity switches is allowed. * Immunologic therapeutic intervention (e.g. IL-2) within the past year * Participation in another clinical drug or device trial where the last dose of drug was within the past 30 days or an investigational medical device is currently implanted * Diagnosis of cancer within the last 5 years (except basal cell cutaneous cancers and cutaneous KS not requiring systemic therapy) * Co-morbid condition with an expected survival of less than 12 months * History of hypersensitivity to vaccination * History of autoimmune disease, such as systemic lupus erythematosis (SLE) or Hashimoto's thyroiditis * Active drug or alcohol use or dependence that, in the opinion of the site investigator, would interfere with adherence to study requirements