Low Dose Human Chorionic Gonadotropin: Influence on the Endometrium

Universitair Ziekenhuis Brussel30 enrolled

Overview

The purpose of the present study is to assess the influence of the administration of low dose hCG on the endometrium. The study is a randomised trial where 2 groups of patients, undergoing a gonadotropin-releasing hormone antagonist protocol for in vitro fertilization, are studied. In addition to the histological findings, by analysing the correlation of the morphological pattern and gene expression profile of human endometrium on the day of oocyte retrieval in patients of both treatment groups, the investigators want to study the implantation potential.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Infertility

Interventions

human menopausal gonadotropinDRUG

200 IU per day in the late follicular phase

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 36 Years

Medical Language ↔ Plain English

Inclusion Criteria: * \< 36 years on day of randomisation * FSH \< 12 in the early follicular phase * Normal ultrasound scan * BMI between 18 and 29 (both inclusive) * Randomisation at outpatient clinic Exclusion Criteria: * Endometriosis ≥ grade 3 * PCO syndrome * Poor responder * Endocrine or metabolic abnormalities

Locations (1)

UZ Brussel

Laarbeeklaan 101, Brussels Capital, Belgium

Outcomes

Primary Outcomes

number of oocytes

Time frame: 2 weeks after start of the treatment

Data from ClinicalTrials.gov

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