Postprandial Inflammation and Fatty Acids

Inclusion Criteria: For all participants: * male gender * 50-70 yrs For diabetic patients only: * BMI \>30 kg/m2 * Well-controlled diabetes: fasting plasma glucose concentration must be \<10.0 mmol/l at the time of screening. * Must be on sulphonylurea- or metformin therapy for at least 6 months with a constant dose for at least two months, or on dietary treatment for at least 6 months2. For obese controls only: * BMI \> 30 kg/m2 * normoglycemic according to WHO criteria (OGTT, fasting blood glucose\< 7 mmol/L, after 2 hr \<7.8mmol/L) For lean controls only: * BMI 18-25 kg/m2 * normoglycemic according to WHO criteria (OGTT, fasting blood glucose\< 7 mmol/L, after 2 hr \<7.8mmol/L) Exclusion Criteria: For all participants: * Female gender * Age below 50 or above 70 years * Hemoglobin levels \<8.4 mmol/L * Allergic to cow milk or dairy products * Allergic to fish oil * Vegetarian * Tobacco smoker * Current or recent (\<4 weeks) use of fish oil supplements or more then four times fish/week; 24.35 g of EPA-DHA of fish per month (800 mg/day) as judged by the questionnaire. * Received inoculations within 2 months of starting the study or planned to during the study * Donated or intended to donate blood from 2 months before the study till two months after the study * Unstable body weight (weight gain or loss \> 3 kg in the past three months) * Medical condition that can interfere with the study outcome (i.e. cardiovascular disease, gastrointestinal disease, renal dysfunction) * Use of medications know to interfere with glucose homeostasis (i.e. corticosteroids) * abuse of drugs and/or alcohol * participation in another biomedical study within 1 month before the first screening visit For obese, type 2 diabetic subjects only: * severe diabetes which requires application of insulin * diabetes-related complications For obese subjects and lean controls only: * hyperglycemic according to WHO criteria (OGTT, fasting blood glucose \>6.0mM, after 2 hr\>11mM) * systolic blood pressure \>160 mmHg or diastolic blood pressure \> 100 mmHg * Urinary glucose concentrations (\>0.25 g/l)