Carbetocin Versus Oxytocin and Hemodynamic Effects

Oslo University Hospital76 enrolled

Overview

A randomized double-blind trial of oxytocin 5 u, carbetocin 100 µg and placebo with hemodynamic response as a primary outcome measure.

Healthy pregnant women sheduled for elective cesarean section. Invasive hemodynmaic monitoring with LiDCO Plus.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Hemodynamic effect of

Hemodynamic effect of

Hemodynamic effect of

Sex: FEMALEMin age: 18 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy pregnant women for planned cesarean section Exclusion Criteria: * Bleeding disorders * Placenta disorders

Division of Anaesthesia and Intensive Care Medicine, Oslo University Hospital - Rikshospitalet

Oslo, Norway

Division of Anesthesia and Intensive Care Medicine

Oslo, Norway

Cardiac Output

The relative change in CO from baseline at the time of delivery up to 2.5 minutes post delivery.

Time frame: 2.5 minutes

Arterial Blood Pressure

The mean change in SAP compared with baseline at the time of delivery up to 2.5 minutes post delivery.

Time frame: 2.5 min

Bleeding

The calculated estimated blood loss from delivery until 2 h after intervention

Time frame: 120 minutes

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