Microenvironment of Adipose Tissue in Endocannabinoid System

Vanderbilt University20 enrolled

Overview

The purpose of this study is examine the relationship between adipose tissue inflammation and activation of the endocannabinoid system before and after Roux-en-Y gastric bypass surgery. The investigators hypothesize that the metabolic improvements and weight loss are due to mechanisms that antagonize the endocannabinoid system.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Obesity

Eligibility

Sex: ALLMin age: 20 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * BMI\>35 kg/m2 * Age 20-60 yrs * Approved and scheduled for gastric bypass surgery * Stable body weight for past 3 months Exclusion Criteria: * Positive pregnancy test * Previous gastric surgeries * Intercurrent infections * History of ketoacidosis or current metabolic acidosis * Serum creatinine or liver function tests \> 2 times upper limits of normal * Taking drugs that are known to affect carbohydrate or lipid metabolism other than anti-diabetes mediations.

Locations (1)

Vanderbilt University Medical Center

Nashville, Tennessee, United States

Data from ClinicalTrials.gov

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