Sirtuin Mediated Effects of 36 Hour Fast and 1 Hour Exercise

University of Aarhus8 enrolled

Overview

Hypothesis: during fasting and exercise will there be an activation of sirtuins (Sirt1). Primarily the investigators will investigate Sirt1 activity in muscle- and fat-biopsies after fasting for 36 hours and after 1 hour of ergometer-cycling at 50 Vo2max. In addition to this the investigators will investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Healthy

Interventions

fast and exerciseOTHER

fasting 36 h and exercise 1 h 50% VO2max

exerciseOTHER

exercise 1 h 50% VO2max

Eligibility

Sex: MALEMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy men * Body mass index (BMI) 20-26 * age 18-45 years Exclusion Criteria: * any kind of disease * any use of medicine

Locations (1)

mikkel Holm Vendelbo

Aarhus, Jylland, Denmark

Outcomes

Primary Outcomes

Sirt1 activity

Time frame: 60 min

Secondary Outcomes

secondary will we investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover.

Time frame: 4 h

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.