Subjects with epilepsy with a documented photoparoxysmal response to intermittent photic stimulation (IPS) will participate. Four subjects will be enrolled at each dose level and will receive a single dose of placebo and a single dose of ICA-105665 during the study, each followed by intermittent photic stimulation. The effects of ICA-105665 on the photoparoxysmal electroencephalography (EEG) response of each group will be reviewed before the dose is selected for each subsequent group of subjects.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
13
Oral tablet. Dose forms of 50 and 100 mg or placebo will be used. A single dose will be administered that can range from placebo or 100 to 600 mg.
Pfizer Investigational Site
Little Rock, Arkansas, United States
Pfizer Investigational Site
Chesterfield, Missouri, United States
Pfizer Investigational Site
Nashville, Tennessee, United States
Change in photosensitivity response
Time frame: begin 1 hr post dose for 8 hours
To correlate plasma concentrations of ICA-105665 with effect on the frequency range of IPS-induced PPR (Photoparoxysmal response) in subjects with photosensitive epilepsy.
Time frame: 3 days
To assess the safety of a single dose of ICA-105665 in subjects with photosensitive epilepsy.
Time frame: 30 days
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