The primary purpose of this study was to determine the effect of dietary weight-loss, exercise training, or a combination of both on physical function in overweight and obese adults with knee osteoarthritis (OA). In secondary analyses, the effect of weight-loss and/or exercise on OA progression, self-reported pain and inflammation were examined. In post-trial analyses, the effect of dietary weight-loss on total mortality was determined.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
318
The goal of the dietary weight-loss intervention was to produce and maintain a mean weight-loss of 5% initial body weight during the 18-month intervention, using dietary counseling and behavior modification.
Participants participated in resistance training (15 minutes) and aerobic exercise (30 minutes) 3d/week for 18-months. The first 4-months of the exercise training were facility-based. After 4-months, participants were allowed to transition to a home-based intervention if they chose to.
Wake Forest University
Winston-Salem, North Carolina, United States
self-reported physical function (WOMAC scale)
Time frame: baseline, 6-months, 18-months
6-minute walking distance
Time frame: baseline, 6-months, 18-months
timed stair climbing
Time frame: baseline, 6-months, 18-months
weight-loss
Time frame: baseline, 6-months, 18-months
self-reported pain
Time frame: baseline, 6-months, 18-months
progression of knee osteoarthritis, measured radiographically
Time frame: baseline, 6-months, 18-months
chronic inflammation, measured according to CRP, IL-6, IL-6 soluble receptor, TNF-alpha, TNF alpha receptors 1 and 2
Time frame: baseline and 18-months
total mortality
Time frame: 7-9 yrs post-trial
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