Safety Study of BMS-816336 in Healthy Male Subjects

Inclusion Criteria: * Healthy male subjects * BMI of 18 to 32 kg/m² * Men only, ages 18-55 years Exclusion Criteria: * Sexually active men not using effective birth control if their partners are WOCBP * Any significant acute or chronic medical illness * Family history of Gilbert's disease * History of Pancreatitis * Evidence of organ dysfunction or any clinically significant deviation from normal in physical examination, vital signs, EGG or clinical laboratory determinations * QTc interval \> 450 msec (corrected for heart rate using Fridericia's correction method, QTcF) * Second- or third-degree A-V block or clinically relevant ECG abnormalities * History of allergy to 11-β-HSD-1 inhibitors or related compounds * Prior exposure to BMS-816336 * Use of St. John's Wort (Hypericum) within 4 weeks prior to the first dose of study drug and throughout the study * Use of an oral, injectable, inhalable or suspension of glucocorticoid agents within 12 weeks of study drug administration * Use of any glucocorticoid topical creams within 4 weeks of study drug administration * Use of oral, injectable, or topical androgen agent within 12 weeks prior to enrollment