Telmisartan as an Adjunctive Treatment for Metabolic Problems in Patients With Schizophrenia

Inclusion Criteria: 1. Age 18-65 years 2. Diagnosis of schizophrenia, any subtype or schizoaffective disorder, any subtype 3. Treatment with clozapine or olanzapine for at least 6 months 4. Stable dose of antipsychotic agent for at least one month 5. Well establish compliance with out-patient medications 6. Females subjects will be eligible to participate in the study if they are of non-childbearing potential or of child-bearing potential and willing to practice appropriate birth control methods (complete abstinence from sexual intercourse, female sterilization, sterilization of male partner, implants of levonorgestrel, injectable progestogen, oral contraceptives, intrauterine devices, or double barrier methods of contraception using spermicide with either a condom or diaphragm) during the study. Exclusion Criteria: 1. Inability to provide informed consent 2. Current substance abuse 3. Psychiatrically unstable 4. Significant medical illness including severe cardiovascular, hepatic, renal disease 5. Current insulin treatment of diabetes 6. History of immunosuppression 7. Current or recent radiation or chemotherapy treatment for cancer 8. Chronic use of steroids 9. Pregnancy or breast feeding 10. Use of diuretics, digoxin, warfarin because the possible drug-drug interaction of telmisartan