The purpose of this study is to determine the effect of probiotics in rotavirus acute diarrhea in children. The investigators will compare the effect of two different probiotics products.
Acute diarrhea remains being the second most frequent infectious condition in children, producing a high number of admissions yearly. In children below one year of age, rotavirus represents the main etiologic agent, both in developed and developing countries. In Bolivia, acute diarrhea affects about 30% of the group below 5 years of age. Probiotics appear as one of the alternatives currently under discussion. Also, evidence available suggests that probiotics shorten the time of diarrhea and therefore the time of rotavirus excretion. In daily practice, we are often limited by the type and number of probiotics products locally available; moreover, information about combined products is scarce. With this in mind, in this study we compared the efficacy of two commercially available products.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
76
S. Boulardii preparation of 1 gram twice daily for 5 days
mixed probiotic preparation 1 gram twice daily for 5 days.
Placebo 1 gram twice daily for 5 days.
Centro Pediatrico Albina Patino
Cochabamba, Departamento de Cochabamba, Bolivia
Duration of diarrhea
Time frame: within the first 72 hours during hospitalization
Duration of fever
Time frame: the first 72 hours during hospitalization
Duration of vomiting
Time frame: the first 72 hours during hospitalization
Duration of hospitalization
Time frame: 4 days
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