This study assesses the long-term safety and tolerability of dasatinib administered to patients with chronic myelogenous leukemia or Philadelphia chromosome positive acute lymphoblastic leukemia and experienced clinical benefit from treatment with dasatinib or imatinib in previous protocols.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
238
Number of Participants Who Died and Had Serious Adverse Events (SAEs), Related SAEs, Adverse Events (AEs) Leading to Discontinuation, Related AEs Leading to Discontinuation, Related AEs, and Related AEs of Special Interest
AE=any new unfavorable symptom, sign, or disease or worsening of a preexisting condition that may not have a causal relationship with treatment. SAE=a medical event that at any dose results in death, persistent or significant disability/incapacity, or drug dependency/abuse; is life-threatening, an important medical event, or a congenital anomaly/birth defect; or requires or prolongs hospitalization. Related=drug-related; having certain, probable, possible, or unknown relationship to study drug.
Time frame: Day 1 of treatment through a maximum of 82 months + 30 days
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Pacific Cancer Medical Center Inc
Anaheim, California, United States
Loma Linda University Cancer Center
Loma Linda, California, United States
Ucla Department Of Medicine
Los Angeles, California, United States
Stanford University School Of Medicine
Stanford, California, United States
Kaiser Permanente Medical Center
Vallejo, California, United States
H. Lee Moffitt Cancer Center & Research Institute
Tampa, Florida, United States
University Of Chicago
Chicago, Illinois, United States
Central Indiana Cancer Centers
Indianapolis, Indiana, United States
University Of Kansas Medical Center
Westwood, Kansas, United States
Dana Faber Cancer Institute
Boston, Massachusetts, United States
...and 62 more locations