The purpose of this study is to determine whether fenoldopam infusion during cardiopulmonary bypass in young children with congenital heart disease is able to reduce indicators of acute kidney injury (biomarkers reduction, diuresis increase) compared to a control group.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
80
Saline continuous infusion during cardiopulmonary by pass at 1 ml/h
Fenoldopam continuous infusion at 1 mcg/kg/min during cardiopulmonary bypass. Infusion preparation is mad in order to match the rate 1 ml/h of placebo infusion.
Bambino Gesù Hospital
Rome, Lazio, Italy
Reduction of urinary and/or serum levels of biomarker NGAL in treated group versus controls
Time frame: End of surgery and 12 hours postoperatively
Reduction of urinary and/or serum levels of cystatin C, increase of diuresis and improvement of perfusion markers in treated group versus controls
Time frame: End of surgery and 12 hours postoperatively
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