A Study of Combination of Temsirolimus (Torisel®) and Pegylated Liposomal Doxorubicin (PLD, Doxil®/Caelyx®) in Advanced or Recurrent Breast, Endometrial and Ovarian Cancer

Inclusion Criteria: * Patients with proven advanced breast cancer, endometrial cancer or ovarian cancer, who are refractory to standard therapies or for whom no standard therapy exists. * Age ≥ 18 years * Patients who have an ECOG status of 0 or 1 * Patients who have a life expectancy of at least 12 weeks * Negative pregnancy test for female patients of childbearing potential * Signed informed consent Exclusion Criteria: * Adequate bone marrow: neutrophils ≥ 1.5 x 109/L, platelets ≥ 100 x 109/L and haemoglobin ≥ 5.0 mmol/l * Adequate renal function: GFR ≥ 60 ml/min * Adequate liver function: ALT and AST \< 2.5 x ULN, total bilirubin ≤ 1x ULN * Fasting level of total cholesterol of no more than 350 mg/dL (9.1 mmol/L) and triglyceride level of no more than 400 mg/L (4.5 mmol/L) * Left ventricular ejection fraction (LVEF) \< 50% * History of serious cardiac disease * Active clinically serious bacterial, viral or fungal infections (\> grade 2). * Known history of human immunodeficiency virus (HIV) infection or chronic hepatitis B or C. * Clinically symptomatic brain or meningeal metastasis. Patients with seizure disorders requiring medication (such as steroids or antiepileptics). Concomitant treatment with strong CYP3A4 inductors (such as rifampicin, St. John´s Wort) or CYP3A4 inhibitors (such as ketoconazole, voriconazole, itraconazole, diltiazem, verapamil, erythromycin) within 2 weeks prior to start. * Moderate or weak CYP3A4 modifiers should be used concomitantly only after careful assessment of risk-benefit ratio. Concomitant use of carbamazepine, phenobarbital, phenytoin or chronic use of dexamethasone is not allowed. (Table 1) * Other concomitant anti-cancer therapy (except steroids) * Concomitant use of streptozocin, mercaptopurine. * Previous treatment with one of the study drugs. * Previous treatment with other mTOR inhibitors * Prior investigational therapy/agents within 4 weeks of start, in case of bevacizumab at least 60 days between bevacizumab discontinuation and first dosing of temsirolimus. * Surgical treatment or radiation therapy in the past 4 weeks. Palliative radiotherapy at focal sites on the extremities is allowed, also within 4 weeks before start * Unresolved toxicity CTC ≥ grade 2 from previous anti-cancer therapy except alopecia. * Known or suspected allergy to any investigational agent or any agent given in association with this trial. * Substance abuse, medical, psychological or social conditions that may interfere with the patients participation in the study or evaluation of the study results * Any condition that is unstable or which could jeopardize the safety of patient and his compliance in the study. * Antracyclines: \> 450 mg/m2 doxorubicin or and \> 600 mg/m2 epirubicin * Medications known to have dysrhythmic potential is not permitted (ie, terfenadine, quinidine, procainamide, disopyramide, sotalol, probucol, bepridil, haloperidol, risperidone, indapamide) * Usage of coumarin-derivate anticoagulants. Low molecular weight heparin is permitted and advised