The study aims to examine the combined effects of delta-9-tetrahydrocannabinol (∆-9-THC or THC) and iomazenil on thinking, perception, mood, memory, attention, and electrical activity of the brain (EEG). THC is the active ingredient of marijuana, cannabis, "ganja", or "pot". Iomazenil is a drug that works opposite to drugs like valium. The purpose of this study is to determine whether the administration of iomazenil will alter the effects of THC.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Enrollment
17
* Iomazenil: 3.7 μg/kg intravenously over 10 minutes * Delta-9-THC (0.015 mg/kg = 1.05 mg in a 70kg individual), dissolved in alcohol. This dose is roughly equivalent to smoking approximately 1/4th of a marijuana cigarette, or "joint". It is administered intravenously for 10 minutes.
Control: small amount of alcohol intravenous (quarter teaspoon), with no THC
VA Connecticut Healthcare System
West Haven, Connecticut, United States
Clinician Administered Dissociative Symptoms Scale
Time frame: On each test day at: baseline, +10min after infusion, +70min, +150min, +240min
Positive and Negative Symptom Scale
Time frame: On each test day at: baseline, +10min after infusion, +70min, +150min, +240min
Visual Analog Scale
Time frame: On each test day at: baseline, +10min after infusion, +70min, +150min, +240min
Auditory Verbal Learning Test
Time frame: On each test day at: baseline, +10min after infusion, +70min, +150min, +240min
Perceptual Aberration Scale
Time frame: On each test day at: baseline, +10min after infusion, +70min, +150min, +240min
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