Palonosetron for the Treatment of Nausea and Vomiting in Terminally Ill Patients

Inclusion Criteria: 1. Patient must be at least 18 years old. 2. Patient must have a terminal diagnosis, with estimated survival of 6 months or less. 3. Patients must have nausea and/or vomiting, not relieved with 1 or more anti-nausea medications. If the patient is treated with an anti-nausea medication, a minimum of 2 hours should pass to ensure that the medication is given a chance to be effective. If there is no relief after 2 hours, then the patient may be treated with palonosetron. 4. Patient's medications must be reviewed. Any medications possibly causing nausea should be stopped if possible. For example, if an opiate is suspected of causing nausea, another opiate should be substituted. However, if this is not effective, or if a medication change cannot be made, then the patient would be eligible for this study. 5. Patient must be able to understand and sign informed consent 6. Patients who have a bowel obstruction that will not be relieved by surgery may be enrolled. This includes patients whose obstruction is technically unresectable, or who are medically too ill to endure a surgery, or who refuse surgical intervention for any reason Exclusion Criteria: 1. Patient has received chemotherapy in the past 28 days. 2. Assessment of possible causes of the nausea and vomiting should be done and recorded. If a reversible cause of the nausea is identified, that cause should be treated if possible. If the treatment relieves the nausea, then the patient is excluded from this study. Possible reversible causes of nausea and vomiting that should be excluded are: * Other medical conditions such as benign positional vertigo, etc.