Abundance and Distribution of Lipids and Proteins in Nonalcoholic Fatty Liver Disease (NAFLD)

N/AEnrolling By InvitationNCT00983463

Vanderbilt University45 enrolled

Overview

Nonalcoholic fatty liver disease (NAFLD) is the most common type of liver disease in the United States. The incidence of NAFLD is very similar to that of obesity, type 2 diabetes, and the metabolic syndrome. The investigators hypothesize that there may be a relationship between over-nutrition, decreased physical activity and the development of fatty liver. The purpose of this study is to identify the types of fats and proteins, and the quantity of each, that are associated with increased severity of NAFLD.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Nonalcoholic Fatty Liver Disease

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 18-65 year of age * Undergoing elective abdominal or bariatric surgery * May have normal or elevated ALT/AST levels Exclusion Criteria: * Presence of viral hepatitis * Significant alcohol use * Intercurrent infections * Use of any thiazolidinediones

Locations (1)

Vanderbilt University Medical Center

Nashville, Tennessee, United States

Outcomes

Primary Outcomes

To identify and relatively quantify, using high performance liquid chromatography electrospray ionization mass spectrometry, select lipids and proteins present in human liver biopsies.

Time frame: 2 years

To spatially profile, using matrix assisted laser desorption ionization time of flight mass spectrometry, select lipids and proteins present in human liver biopsies.

Time frame: 2 years

Data from ClinicalTrials.gov

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