Pain After Laparoscopic Cholecystectomy

Baylor College of Medicine80 enrolled

Overview

To the investigators' knowledge, no study has looked at differences in postoperative pain when comparing maintenance of anesthesia with isoflurane, desflurane, sevoflurane, and propofol in laparoscopic cholecystectomy. The investigators' hypothesis is that total intravenous anesthesia with propofol will lead to less postoperative pain in the first 24 hours after laparoscopic cholecystectomy when compared to maintenance of anesthesia with isoflurane, desflurane or sevoflurane. PURPOSE To find out if maintenance of anesthesia with propofol leads to less postoperative pain after laparoscopic cholecystectomy when compared to maintenance of anesthesia with isoflurane, desflurane, or sevoflurane.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Postoperative Pain

Interventions

Patient induced for general anesthesia as per standard protocol and maintenance of anesthesia provided with Desflurane

SevofluraneDRUG

Patient induced for general anesthesia as per standard protocol and maintenance of anesthesia provided with Sevoflurane

IsofluraneDRUG

Patient induced for general anesthesia as per standard protocol and maintenance of anesthesia provided with Isoflurane

PropofolDRUG

Patient induced for general anesthesia as per standard protocol and maintenance of anesthesia provided with intravenous Propofol infusion

Eligibility

Sex: ALLMin age: 18 YearsMax age: 64 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patient ages 18-64 2. American Society of Anesthesiology Physical Status I, II or III 3. Inpatients scheduled to undergo laparoscopic cholecystectomy at Ben Taub General Hospital Exclusion Criteria: 1. Open cholecystectomy - excluded due to increased levels of pain in open procedures 2. Scheduled for ambulatory surgery 3. Renal dysfunction (Serum Cr \> 1.2) - excluded due to potential altered metabolism of anesthetic and pain medications 4. Allergy to any of the study medications or anesthetic agents 5. Chronic opioid analgesic use at home - excluded due to potential difficulty in assessing pain caused by the procedure alone 6. Patient inability to properly describe postoperative pain to investigators (language barrier, dementia, delirium, psychiatric disorder) 7. Patient or surgeon refusal

Locations (1)

Ben Taub General Hospital

Houston, Texas, United States

Outcomes

Primary Outcomes

Pain Measured on Verbal Scale of 0-10

Pain measured on verbal scale of 0-10, with 0 being absolutely no pain, and 10 being the worst pain in that subjects life.

Time frame: 24 hours

Data from ClinicalTrials.gov

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