Trial of Hematopoietic Stem Cells in Acute Myocardial Infarction

Inclusion Criteria: * Age between 18 and 75 years * Acute myocardial infarction with the following characteristics: * Clinical symptoms of chest pain lasting \>30 minutes, unresponsive to nitroglycerin. * Typical myocardial enzymatical necrotic curve * Total summed ST-segment elevation ≥ 6 mm in 12-lead electrocardiogram. * Akynesis or hypokinesis in infarct-related artery area without contractility abnormalities in the rest of areas. * Pharmacological, mechanical or both type reperfusions (facilitated angioplasty) with evidence of normal infarcted area epicardial flow (TIMI grade 3) in the first 24 hours after the beginning of the symptoms * Successful repair of the infarct-related artery (residual post-stenting stenosis \< 30% by visual estimation with epicardial normal flow \[grade 3\] in the first 24 hours after the beginning of the symptoms or lack of significant residual lesions evidence (\<50% visual estimation) in infarct-related artery. * Lack of evidence of significant lesions in the remaining coronary vessels or adequate revascularization achieved in the first 24 hours after symptoms began. Exclusion Criteria: * The presence of cardiogenic shock defined as sustained systolic blood pressure less than 90 mm Hg, with no response to fluids or systolic blood pressure less than 100 mm Hg with vasopressors (in absence of bradycardia) * Suspicion or evidence of infarct mechanical complication * History of sustained ventricular tachycardia or atrial fibrillation * Patient with cardiac defibrillator or candidate for its potential implantation. * Investigational drug treatment in the previous 4 weeks * Actual or potential use of anti-neoplastic drugs * Oncology antecedents in the last 5 years * Previous treatment with trans myocardial laser revascularization * Women of childbearing potential * Severe concomitant disease modifying patient's survival during the study * Inability to suspend thrombolytic treatment * Active bleeding or major surgery within 2 weeks forbidding the use of heparin, abciximab or antiplatelet therapy. * Previous malignant haematology disease (leukaemia or lymphomas) or hypercoagulability disorders (antiphospholipid syndrome, antithrombin, C-protein and S-protein or V Leiden Factor deficiency) * Previous known renal failure (creatinine \> 2.5 mg /dl) * Any kind of stroke in the last year or whenever episode of haemorrhagic stroke. * Major surgery pending in the next year * Previously known vascular disease that prevents from catheterization. * Evidence of hypersensitivity to Filgrastim, proteins derived from E. coli or any formulation component. * Inability to give written informed consent.