The study will assess the real life effectiveness of zoledronic acid in the management of patients with osteoporosis over 4 years of treatment. Zoledronic acid will be compared to oral bisphosphonates (OBP) with respect to the change in Bone Mineral Density (BMD) and incidence of fractures.
Study Type
OBSERVATIONAL
Enrollment
1,551
Unnamed facility
Vancouver, British Columbia, Canada
Unnamed facility
Hamilton, Ontario, Canada
Groupe de recherche en rhumatologie et maladies osseuses Inc
Québec, Quebec, Canada
Percent change in lumbar spine BMD as measured by dual energy x-ray absorptiometry (DXA)
Time frame: 4 years
change in femoral neck BMD as measured by dual energy x-ray absorptiometry (DXA)
Time frame: 4 years
change in hip BMD as measured by dual energy x-ray absorptiometry (DXA)
Time frame: 4 years
Percent change in hip BMD as measured by dual energy x-ray absorptiometry (DXA)
Time frame: 4 years
Risk for fractures
Time frame: 4 years
Burden of illness, health care resource utilization, and loss of productivity
Time frame: 4 years
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