RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research study is looking at genes in tissue samples from patients with B-cell non-Hodgkin lymphoma.
OBJECTIVES: * To determine if toxicity following treatment for lymphoma varies according to genetic polymorphisms in oxidative stress-related genes (i.e., SOD2, CAT, GPX1, GSTM1, and GSTP1). * To assess whether these genetic polymorphisms are associated with progression-free survival and/or overall survival in these patients treated for lymphoma. OUTLINE: Previously collected samples are used for biomarker analysis.
Study Type
OBSERVATIONAL
Enrollment
337
Association of polymorphisms in oxidative stress-related genes with overall survival and/or progression-free survival
Time frame: retrospectively
Association of polymorphisms in these genes with rate of grade 4-5 hematologic toxicity
Time frame: retrospectively
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