Value of Amphotericin B Inhalation for Prophylaxis of Invasive Pulmonary Aspergillosis After Renal Transplantation

Capital Medical University400 enrolled

Overview

The purpose of this study is to determine whether inhalation with aerosolized amphoterin B 10mg/d is more effective than aerosolized amphoterin B 2mg/d to reduce the incidence of invasive pulmonary aspergillosis.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

400

Conditions

Invasive Pulmonary Aspergillosis

Interventions

Amphotericin BDRUG

Aerosolized Amphotericin B,2mg/day or 10mg/day

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 65ys≥age≥18ys * renal transplant recipients Exclusion Criteria: * subjects with hypersensitivity to amphotericin B * receipt of inhalational or intravenous amphotericin B within last 30 days * subjects with known invasive fungal infection before renal transplant * subjects with pneumonia

Locations (1)

Beijing Chaoyang Hospital,Affiliate of Capital Medical University

Beijing, Beijing Municipality, China

RECRUITING

Outcomes

Primary Outcomes

invasive pulmonary aspergillosis

Time frame: 3 years

Data from ClinicalTrials.gov

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