Infant neurobehavior alteration is predictor of later intelligence development. Many factors would influence or are associated with infant neurobehavior, of which exist or appear during perinatal period. Neuraxial, especially epidural, analgesia to date is the most effective method in relieving labor pain. Although previous studies showed that opioid used in epidural analgesia for labor pain can affect newborn neurobehavior negatively in a dose-escalation associated manner, whether epidural analgesia itself would produce unpredictable effect on newborn neurobehavior is still unknown. Hereby the investigators designed this trial to investigate the hypothesis that epidural analgesia for labor pain control itself would not produce negative effect on infant neurobehavior.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
1,200
Ropivacaine 0.125% plus sufentanil 0.3 microgram
Ropivacaine 0.125% plus sufentanil 0.4 microgram
Ropivacaine 0.125% plus sufentanil 0.5 microgram
Ropivacaine 0.0625% plus sufentanil 0.4 microgram
Ropivacaine 0.1875% plus sufentanil 0.4 microgram
Ropivacaine 0.25% plus sufentanil 0.4 microgram
The Affiliated Nanjing Maternity and Child Health Care Hospital
Nanjing, Jiangsu, China
Neurobehavior evaluation with the Assessment of Preterm Infants' Behavior (APIB)
Time frame: Immediate after birth (0 min)
Apgar scoring
Time frame: One min and 5min after birth.
Umbilical-cord gases analysis
Time frame: At the time baby was born (0min)
Neonatal sepsis evaluation
Time frame: One hour after the baby was born
Neonatal antibiotic treatment
Time frame: One hour after the baby was born
Incidence of maternal side effects
Time frame: Analgesia initiation (0min) to successful vaginal delivery (this time encountered alteration with different women)
Neurobehavior evaluation with the Assessment of Preterm Infants' Behavior (APIB)
Time frame: 10min after birth
Neurobehavior evaluation with the Assessment of Preterm Infants' Behavior (APIB)
Time frame: 1h after birth
Neurobehavior evaluation with the Assessment of Preterm Infants' Behavior (APIB)
Time frame: 8h after birth
Neurobehavior evaluation with the Assessment of Preterm Infants' Behavior (APIB)
Time frame: 1d after birth
Neurobehavior evaluation with the Assessment of Preterm Infants' Behavior (APIB)
Time frame: 1wk after birth
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