Monitoring Organ Donors to Increase Transplantation Results (MOnIToR)

Inclusion Criteria: * Donors who were declared brain dead per local hospital brain death criteria. * Donors who are deemed suitable for organ donation by the local OPO whether they meet the standard criteria or the extended criteria for donation. * Presence of functioning arterial catheter. Exclusion criteria: * Inability to obtain informed consent from donor next of kin or legal representative. * Donors less than 16 years of age, no maximum age limit. * Inability to perform hemodynamic monitoring. * Patients on lithium therapy prior to brain death. * Known severe aortic regurgitation, intra-cardiac shunts, or on intra-aortic balloon pump. * Donors previously enrolled in experimental protocol in which cytokines are the therapeutic targets (e.g. anti-TNF antibodies). * Donors receiving chemotherapy or with any disease state (e.g. AIDS) that renders the subject leukopenic (WBC count \< 2). * Donors receiving anti-leukocyte drugs (e.g. OKT3) regardless of their WBC counts. * Pregnant donors. * Donor is on ECMO machine