Study of the Safety and Efficacy of Apadenoson for Detection of Myocardial Perfusion Defects Using SPECT MPI

Inclusion Criteria: * High pretest probability of CAD based on the ACC/AHA guidelines for relative risk, or past medical h/o CAD Exclusion Criteria: * Ingestion of a caffeinated or methylxanthine food substance (e.g. chocolate, cocoa) within 24 hours before receiving apadenoson or adenosine * Treatment with dipyridamole within 24 hours, or theophylline, aminophylline, or pentoxifylline within 72 hours (or 4 half-lives, whichever is longer) prior to receiving apadenoson or adenosine * Acute MI, new onset of ischemia or PCI within 30 days prior to SPECT-MPI at either Period 1 or Period 2; or CABG within 90 days prior to SPECT-MPI at either Period 1 or Period 2 * Active severe asthma or severe chronic obstructive pulmonary disease (COPD) which, in the Investigator's opinion, places the subject at risk for severe bronchoconstriction * History or evidence of clinically significant cardiac condition and rhythm disorder, in the absence of a functioning permanently implanted pacemaker * Hemodynamically significant valvular disease, outflow tract obstruction, or uncontrolled severe hypertension * Current significant medical, surgical, psychiatric, or other illness or pathology that could potentiate any adverse pharmacological event associated with an investigational drug * Subject with past medical history of hepatitis B or C, or recent hepatitis A * Pretreatment hypotension (systolic BP \< 90 mm Hg) or tachycardia (HR \> 100 bpm) * Known history of cerebral vascular accident or suspected transient ischemic attack within 30 days prior to signed informed consent