A Study To Access The Safety And Tolerability Of RN316 (PF-04950615) When Administered To Healthy Adult Subjects

Inclusion Criteria: * Healthy, ambulatory men and women (of non-childbearing potential) ages 18 -70 inclusive. * Baseline total cholesterol ≥ 200 mg/dl, baseline LDL ≥ 130 mg/dl. * BMI 18.5 to 35, and body weight ≤150 kg, inclusive. Exclusion Criteria: * Evidence of clinically significant disease that may increase the risk to the subject of study participation or interfere with interpretation of results. * Secondary hyperlipidemia. * Subjects who have taken lipid lowering compounds within the past 12 months prior to dosing.