A Study to Evaluate the Safety and Efficacy of Subcutaneously Administered REGN475(SAR164877) in Patients With Sciatic Pain

Inclusion Criteria: 1. Pain present for at least 2 weeks, but not lasting for more than 16 weeks prior to the screening visit. 2. A confirmed diagnosis of sciatica at the screening visit. 3. Weight less than 120 kg Exclusion Criteria: 1. Back surgery within 6 months prior to the screening visit 2. Neurological deficit (muscle weakness and/or reflex loss; loss of bowel or bladder function) from any cause including sciatica 3. Other conditions which may confound the interpretation of the study, such as carpal tunnel syndrome, MS, rheumatoid arthritis, spinal stenosis, etc. 4. Allergy to doxycycline or related compounds 5. Women who are pregnant or nursing