A Study of the Hedgehog Pathway Inhibitor GDC-0449 in Healthy Female Subjects of Non-Childbearing Potential

Inclusion Criteria * Female * Non-childbearing potential * Body mass index (BMI) between 18 and 32 kg/m\^2, inclusive * In good health, determined by no clinically significant findings on physical examination, medical history, 12-lead ECG, and vital signs * Negative test for drugs of abuse at screening (does not include alcohol) and at admission to the clinical research facility (does include alcohol) Exclusion Criteria * History or clinical manifestations of clinically significant metabolic, hepatic, renal, hematologic, pulmonary, cardiovascular, endocrine, gastrointestinal (including gastric or duodenal ulcers), urologic, neurologic, inflammatory, or psychiatric disorders, or cancer * History of symptomatic hypotension, idiopathic orthostatic hypotension, or other autonomous-failure syndromes * History of severe physical injury, direct impact trauma, or neurological trauma within 6 months prior to Day -1 * History of stomach or intestinal surgery, stomach disease, or resection that would potentially alter absorption and/or excretion of orally administered drugs (appendectomy, hernia repair, and/or cholecystectomy are allowed) * History of alcoholism, drug abuse, or drug addiction (including soft drugs like cannabis products) * Use of any prescription medications/products, including known enzyme-inducing/inhibiting agents, over-the-counter medication, or other non-prescription preparations (including supplements, vitamins, minerals, phytotherapeutic/herbal/ plant-derived preparations, the tryptophans, and St. John's wort or other hypericum perforatum-containing substance) within 2 weeks prior to Day -1, with the exception of hormone-replacement therapy * Participation in any other investigational drug study in which receipt of an investigational study drug occurred within 60 days prior to Day -1 or within 5 times the elimination half-life of the respective drug; participation in a trial involving administration of \^1\^4C-radiolabeled compound(s) within 6 months prior to Day -1; participation in more than two other drug trials within 1 year prior to Day -1 * Receipt of any vaccination or immunization within 1 month prior to Day -1 * Use of any nicotine-containing or nicotine-replacement products within 6 months prior to Day -1 * Consumption of alcohol or methylxanthine-containing beverages or food * Receipt of blood products within 2 months prior to Day -1 * Donation of \> 100 mL of blood within 60 days prior to Day -1; donation of \> 1.0 litres of blood within 10 months prior to Day -1 * Irregular defecation pattern, i.e., less than once per 2 days within 6 months prior to Day -1; acute constipation problems within 3 weeks prior to Day -1 (Part B subjects only) * Poor peripheral venous access