Plaque Registration and Event Detection In Computed Tomography

Hiroshima University3,015 enrolled

Overview

Disruption of an atherosclerotic plaque is responsible for at least two-thirds of acute coronary syndrome. Thus, identification of plaques vulnerable to rupture has become important. The natural history of individual plaques is unknown and needs to be established. Multidetector computed tomography (MDCT) angiography is a useful noninvasive imaging modality for assessing coronary plaque characteristics. Using MDCT, the researchers prospectively investigate the relationship between the characterization of coronary plaques and cardiovascular events in a large multicenter study.

Study Type

OBSERVATIONAL

Enrollment

3,015

Conditions

Atherosclerosis Cardiovascular Diseases Coronary Artery Disease

Eligibility

Sex: ALLMin age: 20 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients with known or suspected coronary artery disease. Exclusion Criteria: * irregular heart beat, * known allergy towards the contrast agent, * renal dysfunction, * uncontrolled heart failure, * previous coronary bypass surgery, or pacemaker or ICD implantation, ST elevation MI or unstable hemodynamic condition, * impossible breath-hold, OR * end-stage cancer.

Locations (1)

Outcomes

Primary Outcomes

Major cardiac events (Cardiac death and acute coronary syndrome)

Time frame: 2 years after the CT-scan

All-cause death

Time frame: 2 years after the CT-scan

Secondary Outcomes

All coronary events (Cardiac death, non-fatal MI, unstable angina requiring hospitalization, late coronary revascularizations)

Time frame: 2 years after CT-scan

All cardiovascular events (Death, acute coronary syndrome, heart failure, cerebral disease, peripheral artery disease, aortic disease, and renal failure)

Time frame: 2 years after the CT-scan