Inflammation, Immune Activation and Portal Hypertension in Alcoholic Hepatitis

University of Aarhus60 enrolled

Overview

The purpose of this study is to investigate the role of endotoxins and the endotoxin mediated immune activation pathway in patients with alcoholic hepatitis. Also, to determine the effect of Liver assist (liver dialyses) intervention on these parameters in patients with severe alcoholic hepatitis.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Alcoholic Hepatitis

Interventions

Prometheus Liver Dialysis system (Fresenius Medical Care)DEVICE

6 hour dialysis for 3 consecutive days

Eligibility

Sex: ALLMin age: 18 YearsMax age: 69 Years

Medical Language ↔ Plain English

Inclusion Criteria: Patients with alcoholic hepatitis based on the following criteria * Alcohol intake for 6 consecutive months above 40g /day, at admission or 3 months earlier. * Serum bilirubin level above 80 mmol/l * exclusion of other types of liver disease. * Liver biopsy when diagnosis is unclear. Exclusion Criteria: * Heart failure * Pregnancy * non fluent danish speakers

Locations (1)

Department of Medicine V, Aarhus University Hospital

Aarhus, Denmark

Outcomes

Primary Outcomes

Serum endotoxin levels

Time frame: one year

Secondary Outcomes

Endotoxin activation pathway proteins

Time frame: 1 year

Data from ClinicalTrials.gov

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