Intravitreal Ranibizumab For Persistent New Vessels In Diabetic Retinopathy(Inipe Study)

Inclusion Criteria: * persistent new vessels,defined as fine retinal vessels with dilated buds or tips covered with hemorrhage or associated with recurrent vitreous hemorrhage or paucity of accompanying fibrous tissue and/or increased in extent compared to previous visit,unresponsive to complete panretinal laser photocoagulation performed at least 4 months prior; * logarithm of minimum angle of resolution (logMAR) best-corrected visual acuity of 0.17 (Snellen equivalent, 20/30) or worse. Exclusion Criteria: * history of vitrectomy in the study eye; * history of thromboembolic event (including myocardial infarction or cerebral vascular accident); * major surgery within the prior 6 months or planned within the next 28 days; * uncontrolled hypertension; * known coagulation abnormalities or current use of anticoagulative medication other than aspirin.