Our hypothesis is double insemination will improve pregnancy rates in coh cycles with more than one dominant follicles (\>16mm).
Metaanalysis for the effects of double IUI demonstrates that effects of this procedure is not different from single IUI. It is known that nearly 25% of coh cycles is evident by monofollicular development.For this reason it is possible that this monofollicular cycles in the studies could decrease the effects of double IUI. Inclusion criteria: 1. Patients with unexplained infertility or mild male factor infertility whom admitted to the COH+IUI programme in our infertility unit. 2. Female age \<37 years old. 3. Baseline FSH \<12 mIU/L 4. Total antral follicle count\>6 5. During the first three cycles of COH+IUI 6. Minimum 2 follicles \>16 mm at the day of HCG. Primary outcome: Ongoing pregnancy rates Secondary outcomes: The effects of different coh regimens (CC,FSH,CC+FSH)on the outcomes.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
228
Single IUI after 36-38 hours of HCG
Double insemination after 18 and 40 hours of HCG administration.
Baskent University Medical Faculty Obstetric and Gynecelogy Department, Infertility and IVF unit
Adana, Turkey (Türkiye)
ongoing pregnancy rates
Time frame: pregnancy >12 weeks of gestation
The effects of different coh regimens on outcomes
Time frame: 14 days after IUI procedure
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