Pilot Trial of Bupropion Versus Placebo for Methamphetamine Abuse in Adolescents

Inclusion Criteria: 1. age 14 years to 21 years of age, inclusive; 2. meet DSM-IV criteria for methamphetamine abuse or dependence as determined by the K-SADS-PL; 3. seeking treatment for MA problems; 4. report MA use on 18 or fewer of the past 30 days at baseline; 5. willing and able to comply with study procedures; 6. willing and able to provide informed assent (for youth \<18 yr) or consent (for youth ≥18 yr) and parents willing to provide informed consent (for youth \<18) to participate in the project; and 7. able to complete study assessments in English due to the lack of some measures in Spanish; 8. if female, not pregnant or lactating and willing to use an acceptable method of barrier birth control (e.g. condoms) during the trial. Exclusion Criteria: 1. have a medical condition that, in the study physician's judgment, may interfere with safe study participation (e.g., active TB, unstable cardiac, renal, or liver disease, unstable diabetes); 2. have a current neurological disorder (e.g., organic brain disease, dementia) or major psychiatric disorder not due to substance abuse (e.g., schizophrenia, bipolar disorder) as assessed by the K-SADS-PL other than attention deficit-hyperactivity disorder (see below) or a medical history which would make study agent compliance difficult or which would compromise informed consent, or history of suicide attempts in the past year and/or current serious suicidal intention or plan as assessed by the K-SADS-PL; 3. currently taking bupropion for depression, smoking cessation or OCD within 30 days of baseline; 4. taking any prescription medication for ADHD; 5. currently on prescription medication that is contraindicated for use with bupropion; 6. have current dependence on cocaine, opiates, alcohol, or benzodiazepines as defined by DSM-IV-TR; 7. have a self-reported history of a seizure disorder or serious closed head injury; 8. have a medical condition (such as serious head injury) that is associated with increased risk of seizures or on a medication that lowers the seizure threshold; 9. have a current or past history of anorexia or bulimia; 10. body weight less than 50kgs; 11. have current hypertension uncontrolled by medication; 12. have a history of sensitivity to bupropion; and 13. any other circumstances that, in the opinion of the investigators, would compromise participant safety.