A Study With Peptide Vaccination in Treating Patients With Esophageal Cancer

Inclusion Criteria: DISEASE CHARACTERISTICS * Locally advanced, recurrent or metastatic esophageal squamous cell carcinoma who had failed for the standard therapy PATIENTS CHARACTERISTICS * ECOG performance status 0-2 * Age≧ 20≦ 80years * WBC≥ 2,000/mm³ Platelet count ≥ 75,000/mm³ Total bilirubin ≤ 2.0 x the institutional normal upper limits AST, ALT, ALP ≤ 2.5 x the institutional normal upper limits Creatinine ≤ 1.5 x the institutional normal upper limits * No therapy 4 weeks prior to the initiation of the trial * Able and willing to give valid written informed consent Exclusion Criteria: * Pregnancy (women of childbearing potential: Refusal or inability to use effective means of contraception) * Breastfeeding * Serious bleeding disorder * Serious infections requiring antibiotics * Concomitant treatment with steroids or immunosuppressing agent * Decision of unsuitableness by principal investigator or physician-in-charge