The researchers will investigate whether caloric restriction or dietary supplementation could provide positive effects on general brain functions in healthy elderly people.
The age-related degradation of cognitive functions even to the point of neurodegenerative disorders such as Alzheimer's disease are a growing public-health concern with devastating effects. Referring to animal data, empirical studies, and pilot human trials, a healthy diet rich in unsaturated fatty acids and low in calories should improve cognitive functions such as learning and memory. To test this hypothesis, the researchers study general brain functions in healthy elderly subjects (50-80 years old) during a short term diet.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
300
20-30% CR for 6 months
2g/day DHA/EPA capsules for 6 months
Daily corn oil capsules for 6 months
Department of Neurology, Charité Universitätsmedizin Berlin
Berlin, State of Berlin, Germany
RECRUITINGAuditory verbal Learning Task
Time frame: Baseline (timepoint 0), after 6 months (timepoint 6 months)
Functional/Structural brain changes
Time frame: Baseline (timepoint 0), after 6 months (timepoint 6 months)
Plasma biomarkers
Time frame: Baseline (timepoint 0), after 6 months (timepoint 6 months)f intervention
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
daily resveratrol for 6 months