Benefit of CoQ-10 in Patients on Statins

Inclusion Criteria: 1. Adult men and women 21 years and older taking statin medications for hyperlipidemia under the current National Cholesterol Education Program guidelines (NCEP III) and complaining of myopathic symptoms. Exclusion Criteria: 1. diagnosis of cancer; 2. acute illness of any sort; 3. hemoglobin less than 12, 4. creatinine greater than 1.5 mg/dl; 5. liver dysfunction as evidenced by elevations in transaminases 3-fold higher than upper limit of normal; 6. use of certain medications or nutritional supplements within the past month; 7. untreated hypertension (diastolic BP\> 100 mm HG); 8. diagnosis of diabetes mellitus (fasting blood glucose \> 126 mg/dl); 9. untreated hypothyroidism; 10. overt congestive heart failure (by physical exam); 11. active inflammatory diseases such as rheumatoid arthritis, lupus, etc., 12. bleeding disorders; 13. history of adverse reactions besides myopathy associated with the use of statins; 14. any previous adverse reaction to coQ10 or to multivitamin supplements containing coQ10; 15. plasma CPK levels \> 3 times the upper normal limit; OR 16. congenital myopathies and/or neuromuscular degenerative diseases.