An Exploration of Genetic Testing for Prostate Cancer Susceptibility

Inclusion Criteria: * Men with a positive family history of prostate cancer. The definition of a positive family history will be: Men with a first degree relative with prostate cancer diagnosed at \<70 years; Men with two relatives with prostate cancer where at least on is diagnosed at \<70 years; Men with three relatives with prostate cancer diagnosed at any age * Age 40-69 years * No previous biopsy for raised PSA * Absence of any psychological, familial, sociological or geographic situation potentially hampering compliance with the study protocol and follow-up schedule. Exclusion Criteria: * Previous prostate cancer * Men from families where there is known to be a mutation in a high-risk prostate cancer gene * Men who have had a prostate biopsy within the last 12 months.