The purpose of the study is to determine the efficacy of two different algorithms for coagulation management in patients undergoing cardiac surgery suffering from increased bleeding tendency. Algorithm 1 is based on conventional coagulation analyses (INR, aPTT, platelet count, fibrinogen concentration,...) and Algorithm 2 is based on thrombelastometry using the ROTEM-device and impedance aggregometry using the Multiplate device.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
SINGLE
Enrollment
200
Patients are randomized to receive either point-of-care based or conventional coagulation measurements based coagulation therapy in the case of increased perioperative bleeding tendency
University Hospital Essen, Clinic for Anesthesiology and Intensive Care Medicine
Essen, Germany
Johann Wolfgang Goethe University Frankfurt, Clinic for Anaesthesiology
Frankfurt am Main, Germany
amount of transfused red blood cell concentrates
Time frame: 24 h after begin of surgical intervention
other transfused blood products including FFP, platelet concentrates and coagulation factor concentrates
Time frame: 24h after surgical intervention
rate of rethoracotomy for bleeding
Time frame: 24h after surgical intervention
ventilation time on ICU
Time frame: till discharge from ICU
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